Research


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Latest Projects

Research project (§ 26 & § 27)
Duration : 2017-03-01 - 2019-02-28

Aim of the project between EGGER and BOKU is to develop a binder for wood based on lignin, isolated from black liquor, a waste stream of the pulp and paper industry. The project will search for appropriate methods to provide isolated lignin. In a subsequent step the lignin will be comprehensively characterized based on methods developed at the Department of Chemistry, Division of Chemistry of Sustainable Resources.
Research project (§ 26 & § 27)
Duration : 2015-07-01 - 2018-06-30

This proposed research project will elucidate the specific triggers of ascaridole (Asc) activation in these cells and the preferred targets that cause cytotoxicity in Leishmania and might contribute to selectivity. Specifically, the role of heme iron and the low molecular labile iron pool in Asc activation will be studied with electron spin resonance (ESR) spectroscopy. Mechanism studies will be supported by the synthesis of Asc-related endoperoxides and the use of non-endoperoxide Asc analogues to enable structure activity relationship studies. The role of selective toxicity will be addressed by comparison studies with monocyte/macrophage cell lines as well as with mammalian detoxification enzymes. Findings of the mechanism studies relevant for treatment will be verified in a mouse model of cutaneous leishmaniasis. Based on the details of the mechanism of action of Asc, the synergistic/antagonistic role of chemotherapeutic metal-chelating ligands in their action against Leishmania will be identified. The mechanism details revealed in this project will help to understand the conditions for effective application of Asc-related endoperoxides as antileishmanial drugs.
Research project (§ 26 & § 27)
Duration : 2014-10-01 - 2018-06-30

The research project "Chromopres and cellulose aging" addresses the generation of chromophoric substances in cellulosic matrices and its underlying chemical mechanisms, novel opportunities to analyze chromophores and their presurcors on a molecular level, and new ways to minimize yellowing and optimize pulp bleaching sequences. The six work packages (WP1 - WP6) cover three closely interrelated topics. WP1 to WP3 address the question how process conditions and individual bleaching steps influence the content of carbonyls (precursor moieties for chromophores) in cellulose. This requires appropriate analytical methodology to be optimized and newly developed (chromatographic and spectroscopic techniques). The second group of work packages (WP4 - WP5) deals with metal ion management and the influence of metal ions on product quality (pulp, fibers, paper). The connection between chromophores and impurities, such as metal ions or extractives from the starting material) is studied. In order to optimize bleaching sequences, the mechanisms and products of the degradation of key chromophores under standardized bleaching conditions are investigated in WP6, building on results of the previous "Chromophore I" project.

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