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Research project (§ 26 & § 27)
Duration : 2019-03-01 - 2023-02-28

The major aims of this project are related to galactose in Entamoeba histolytica in terms of its metabolism and incorporation into glycoconjugates, whereby galactose is a known component of the cell surface lipopeptidophosphoglycan (LPPG) as well as of N-glycans. However, other than the predicted occurrence of UDP-galactose epimerase, there is currently little information regarding galactose metabolic and transfer reactions in this parasite.
Research project (§ 26 & § 27)
Duration : 2018-12-01 - 2022-11-30

Wood cellulose is a future super material for replacement many fossil-based products. Modification of the wood-pulp is needed for the preparation of value added products. Enzymes are specific, renewable and biodegradable tools for modification of the pulps in mild reaction conditions. Recently discovered novel types lytic polysaccharide monooxygenases, are enzymes that oxidize cellulose in the crystalline parts, thus representing a novel type of enzyme activity with capability to modify the most recalcitrant celluloses. This project will explore the potential of LPMOs in oxidative modification of cellulosic fibres. The consortium brings together top-class expertise in enzymatic modification of pulp and fibre applications, LPMO enzymology and cellulose analytics
Research project (§ 26 & § 27)
Duration : 2018-12-05 - 2021-12-04

Despite the significant advantages that combining ion mobility mass spectrometry with all-ions QTOFMS, the highly complex nature of samples faced in metabolomics studies still poses great challenges for routine use of such workflows in metabolomics. One approach to address this limitation is the use of drift-time dependent quadrupole transmission profiles to facilitate a “bandpass” selection of precursor ions to be fragmented in the collision cell. In such a workflow, the transmission and/or collision energy applied in the high energy frame can be further directed by the drift separation (i.e. the quadrupole transmission is programmed to suit the drift times of relevant metabolites). This technology has enormous potential for metabolomics, but has not been tested or assessed with relevant compounds or real samples. In this project, we propose to investigate the use of continuous wide-band quadrupole isolation in combination with ion mobility separation to establish optimized acquisition settings and comprehensive datamining workflows with an outlook toward critical applications covering both identification and relative quantification in biological and environmental samples.

Supervised Theses and Dissertations