H773 Abteilung für Organische Chemie
Nicht eingeloggt
Glycochemistry
The main research topic of the group is based on the role of carbohydrates in eliciting or modulating adaptive as well as innate immune responses.
Research interests are focused on the immunochemistry and structural biology of complex carbohydrates of microorganisms (bacteria, viruses, parasites) and key expertise has been developed in the chemical synthesis of oligosaccharides, glycophospholipids, nucleotide-activated sugars and neoglycoconjugates.
- The chemical synthesis of Inner core and Lipid A structures of bacterial lipopolysaccharides and their conversion into artificial antigens has been accomplished to investigate antigenic properties of the core region as well as the immunobiology of synthetic Lipid A ligands from Chlamydia, Francisella, Burkholderia and Pseudomonas species.
- Evaluation of the binding modes of Kdo antigens within the binding sites of germline derived antibodies (Cooperation with H. Brade, S. Evans).
- Synthesis and biosynthesis of nucleotide-activated bacterial heptoses such as ADP and GDP heptose.
- Lectin recognition involving heptosyl units of bacterial LPS (Cooperation with E. Crouch, J. Head, A. Imberty).
- Modulation of the immune response by cell-surface sugars from parasites.
- Synthetic neoglycoconjugates to be used in the clinical diagnosis of parasitic Toxocara canis infections.
- The Antiviral Spot of Excellence project jointly with TU Vienna and Onepharm is dedicated to chemical modification of the plant-derived drug glycyrrhizin
- Synthetic modification of wood derived hemicelluloses (WOOD COMET)
